Demonstration of Agglutinins for Bartonella Bacilliformis
نویسنده
چکیده
1. Methods of preparing a satisfactory antigen having been developed, a technique for performing an agglutination test with B. bacilliformis is made available. 2. As a result of repeated intravenous injection of living cultures of B. bacilliformis at short intervals, rabbits have been found to produce a high titre of specific agglutinins which, under the conditions obtaining in the present series of experiments, begins to decline after about one month following the last inoculation. 3. Sera from six cases of bartonellosis in different stages of its several manifestations have been shown by the agglutination test to contain a low but definite titre of circulating antibody. 4. Several of these same sera have been shown to contain as well a significantly high titre of agglutinins for three strains of Proteus. No definite conclusions can be drawn from this phenomenon since the case histories had not been probed for the possibility of typhus fever; and since the relatively high titres obtained with a few of the present sera may very well fall within the extremes of normal serum titres.
منابع مشابه
Establishing a direct role for the Bartonella bacilliformis invasion-associated locus B (IalB) protein in human erythrocyte parasitism.
The invasion-associated locus A and B genes (ialAB) of Bartonella bacilliformis were previously shown to confer an erythrocyte-invasive phenotype upon Escherichia coli, indirectly implicating their role in virulence. We report the first direct demonstration of a role for ialB as a virulence factor in B. bacilliformis. The presence of a secretory signal sequence and amino acid sequence similarit...
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Bartonella bacilliformis is the causative agent of Carrion's disease, a highly endemic human bartonellosis in Peru. We performed a whole-genome assembly of two B. bacilliformis strains isolated from the blood of infected patients in the acute phase of Carrion's disease from the Cusco and Piura regions in Peru.
متن کاملWhole Genome Sequencing and Comparative Analysis of Bartonella bacilliformis Strain INS, the Causative Agent of Carrion’s Disease
Bartonella bacilliformis is the etiological agent of human bartonellosis, which is highly endemic to Peru. Here, we report the first genome that was sequenced and analyzed from an isolate of B. bacilliformis strain INS, which originally was isolated from the blood of an infected patient with an acute phase of Carrion's disease from Jaén-Cajamarca, Peru.
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 75 شماره
صفحات -
تاریخ انتشار 1942